cause disease gout - How Do I Know I have Arthritis ?
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How Do I Know I have Arthritis ?

There are pain syndromes like fibromyalgia and arthritis-related disorders, such as systemic lupus erythematosus, that involve every part of the body. There are relatively mild forms of tendinitis (as in 'tennis elbow') and bursitis to crippling systemic forms, such as rheumatoid arthritis. There are forms of the disease, such as gout, which almost nobody connects with this condition, and there are other conditions - like osteoarthritis, the misnamed 'wear and tear' arthritis - that a good many people think is the only form of the disease.


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A combination of exercise, diet, rest and relaxation is important in achieving an optimum level of health and wellness. Light exercise such as brisk walking helps to keep the joint cartilage lubricated. It also strengthens the supporting muscles, tendons and ligaments and increases the range of motion and flexibility of the joints.

This suggests that progression of the disease may be contained in difficult-to-treat cases, and therefore may not cause other medical conditions such as kidney stones heart disease and hypertension.

If a person is on many medications, which can cause gout, changing these may help. One common cause is diuretic medications, which decrease leg swelling or edema. Many older individuals are on these medicines and if they get a gout attack they must remember this fact.

The relief of pain is remarkable with some of the anti-inflammatory medicines also called NSAIDS or non-steroidal anti-inflammatory medications. The typical example is indomethacin or ibuprofen. Applying local ice or heat may sometimes help as well as keeping the joint without moving or bumping into objects.

Celery seeds neutralise uric acid and other excess acids in the body, thus aiding in the treatment and prevention of gout, joint pain and rheumatism. Guaiacum has an anti-rheumatic action which is beneficial not only for stiff and painful joints but also affected muscles. The combination of celery seeds, guaiacum, ginger, capsicum and sarsaparilla effectively reduces inflammation and soothes the pain.

Gout is caused by the increase in the amount of uric acid in the blood. Uric acid is normally removed from the body through the urine, however if it is not excreted it can form crystals, which irritate body tissues like the lining of joints. This will in turn cause inflammation and pain, which is often quite severe.

Pegloticase's answer to the excess uric acid level problem is to remove it by ingeniously converting uric acid into something else, a substance called Allantoin. Allantoin is more soluble and better excreted than uric acid. The principle comes from the way most animals do it. They do it by converting UA to Allantoin, but this is something humans cannot do naturally. Hence the formulation of Pegloticase.

In other patient groups there were reductions in attacks and improvement in tophi reduction. Tophi are those knobbly shaped, awkward looking, lumps of MSU crystals that often develop in longer term gout sufferers.

TRIAL SUCCESS WITH DIFFICULT TO TREAT GOUT PATIENTS Pegloticase is significant because its trials have focused on gout patients who have not had success with other gout drugs, or who have medical conditions which prohibit the use of them. Thus it has been tackling harder-to-treat gout cases, not the easier ones. Hard to treat cases are a significant percentage of the gout sufferer universe.

In some situations steroid medications like prednisone may be needed. The steroids will decrease the inflammation and decrease the chemical responses that cause pain. It is important to know that there are many side effects from all of the medications and you must discuss these with your healthcare provider.

Pegloticase is getting closer to an application for approval by the U.S. FDA. Its developers hope to apply for a Biologics Licence Application in September 2008, and begin marketing it in 2009.

Other encouraging statements were that all extension trial patients who had responded earlier to treatment and who were on the every two week course maintained normal uric acid levels, (some were new joiners). 70% of those on an every four week course who had responded earlier to treatment, maintained normal uric acid levels.

31% of patients who had not reduced tophi at the end of these phase 3 trials did show tophi reduction in the extension trial. It would seem that the longer a gout sufferer is able to take Pegloticase the more successful it may be, in tophi cases at least.

There are several common misconceptions about arthritis. Myth # 1 is that every day is the same for patients. In reality, this form of chronic pain comes and goes, which makes it difficult for diagnosis. Myth # 2 is that only older people have arthritis. However, in some cases, even children have this type of pain. Myth # 3 is that arthritis is caused by cold, wet weather or a poor diet.

As with all medications make sure you do not have an allergy to them and sometimes taking the medicine with food may decrease stomach upset or gastric distress, especially medicines like steroids.

In reality, there are no easy cause-and-effect connections, but contributing factors include: age, weight, anatomy, infection of the joint and trauma. Lastly, some believe that joint replacement surgery (arthroplasty) should be avoided for as long as possible. Yet the surgery has helped millions of Americans and is seen as a viable option when exercise, physical therapy and medication fail.

In May 2008 the U.S. based company developing Pegloticase made another upbeat statement assessment of what they have learnt in its Phase 3 and open label extension trials. Note that Pegloticase still awaits approval from medical authorities so I am writing here about a new gout drug that is still under development.

For people with gout, NSAIDs, Corticosteroids, Allopurinol and Probenecid are effective drugs. Be sure to see your doctor if you have been suffering with any symptom of chronic pain.

 
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HOW PEGLOTICASE WORKS What makes Pegloticase a very interesting, and more importantly, a hopeful new gout drug, is the way it works. All drugs used in gout try to cure or alleviate the disease by reducing the body's uric acid (UA) levels. They do this by either inhibiting its production or making it easier to remove.

SIDE EFFECTS Of course Pegloticase has caused side effects, in the extension trial in about 1 in 5 patients. The developing company has said that most were mild, moderate, or controllable. But in some cases more severe side effects have been described as including chest and back pains, muscle cramps, sweating and flushes.

In some gout attacks patients may need joint fluid removed for analysis and during the process can have local numbing medicines injected into the joint. These numbing medicines are also called local anesthetics. Sometimes steroids are injected into a joint to decrease the inflammation.

Colchicine is typically used if the first line medications like NSAID's do not help but most people have relief of pain ultimately. Even if no medicines are taken the attack will subside in a few days. However if repeated attacks occur there can be lasting damage.

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May was a good month for gout sufferers. Febuxostat, (EU trade/brand name Adenuric), the first new major drug medication for gout in over 40 years, was approved for marketing in member countries of the European Union.

Have sufficient rest as fatigue or even mild tiredness can exacerbate arthritis. Healthy weight management is also important as being overweight can burden the joints, especially the knees, thus aggravating the pain. You may also consider Bowen therapy, a series of precise connective, non-invasive tissue moves that stimulates the energy flow and activates the body's natural healing ability.

Besides that, alcohol, coffee and foods rich in purine such as seafood, beans, sweetbreads and anchovies should be avoided. Try to increase intake of food high in dietary fibre (vegetables and fruits) and complex carbohydrates (oats, barley, bran).

For treatment, Methotrexate slows the progression of rheumatoid arthritis and restores some function. For osteoarthritis sufferers, NSAIDs like ibuprofen are good at relieving short term pain and stiffness. Disease modifiers like Methotrexate, Leflunomide, Adalimumab, Etanercept or Infliximab can help long term effects and reduce joint damage.

How do you know if you have arthritis? While symptoms and severity vary from person to person, the most common symptoms are: pain, swelling, stiffness, tenderness, redness and warmth. Osteoarthritis is characterized by progressive stiffness without swelling, chills or fever.

NB. The contents of this article contain medical information not medical advice. Please always discuss gout remedies with your doctor or other health care professional, before implementing any treatment.

Rheumatoid arthritis is the painful swelling, inflammation and stiffness in the fingers, arms, legs and wrists, which are prevalent on both sides of the body and are usually worse in the morning. Children with on-off fever, loss of appetite, weight loss and a blotchy rash on the arms and legs might have juvenile rheumatoid arthritis. You should call the doctor if symptoms appear suddenly, or if they are accompanied by a fever or rash.

It has been having a decent degree of success. Elimination of gout attacks In its most recent statement the developing company's most significant remark was that the extension trial group receiving Pegloticase every two weeks, there were only four gout attacks among those who had been administered Pegloticase (8 mg) every fortnight for two months, in subsequent months. And none in this group had a gout attack after five months of Pegloticase treatment, in following months. All were patients who had been through a phase 3 trial.

In the world of natural gout remedies, uric acid's removal can be improved by making it more soluble. This is achieved by drinking lots of water and by raising body pH levels in various ways.

Answer : GOUT is a painful and potentially disabling form of arthritis. It causes pain, tenderness, redness, warmth and swelling in some joints. This is due to the increasing levels of uric acids in the body.

Question : I'M a 55-year-old man who has been suffering from joint pains for a couple of years. I've consulted my family doctor and was told I'm affected with gout. Is there any natural remedy for this?

Mike Selvon owns a number of niche portal. Please visit our portal for more great information on arthritis myths, and leave a comment at our arthritis treatment blog.

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